Matthew J Flick Selected Research

estropipate (Ogen)

1/2022	Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity.
1/2022	Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.
10/2021	Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth.
1/2019	Does fibrinogen serve the host or the microbe in Staphylococcus infection?
1/2019	The multifaceted role of fibrinogen in tissue injury and inflammation.
1/2019	Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation.
8/2017	Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
1/2017	Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12.
10/2015	Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.
8/2014	Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Matthew J Flick Research Topics

Disease

20	Inflammation (Inflammations) 01/2022 - 07/2009
15	Neoplasms (Cancer) 01/2022 - 01/2005
11	Thrombosis (Thrombus) 01/2022 - 07/2009
7	Infections 01/2022 - 03/2013
7	Hemorrhage 01/2022 - 06/2012
7	Afibrinogenemia (Fibrinogen Deficiency) 01/2022 - 11/2007
7	Arthritis (Polyarthritis) 05/2020 - 11/2007
6	Peritonitis 01/2022 - 01/2009
4	Colonic Neoplasms (Colon Cancer) 10/2021 - 04/2010
4	Staphylococcal Infections 01/2021 - 03/2013
4	Joint Diseases (Joint Disease) 03/2017 - 11/2007
4	Neoplasm Metastasis (Metastasis) 10/2015 - 01/2005
3	Venous Thrombosis (Deep-Vein Thrombosis) 01/2022 - 08/2014
3	Adenocarcinoma 10/2021 - 10/2015
3	Osteoporosis 01/2021 - 08/2014
3	Obesity 01/2021 - 08/2017
3	Fibrosis (Cirrhosis) 01/2021 - 01/2016
3	Wounds and Injuries (Trauma) 05/2020 - 08/2015
3	Experimental Arthritis 03/2017 - 11/2007
3	Necrosis 01/2017 - 10/2015
2	Acute-Phase Reaction 01/2022 - 05/2020
2	Colitis 01/2020 - 06/2014
2	Bacterial Infections (Bacterial Infection) 01/2019 - 06/2016
2	Carcinogenesis 01/2019 - 06/2014
2	Fatty Liver 08/2017 - 11/2014
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017 - 03/2007
2	Neuroinflammatory Diseases 01/2017 - 03/2007
2	Paralysis (Palsy) 01/2017 - 03/2007
2	Colitis-Associated Neoplasms 06/2014 - 04/2010
2	Adenoma (Adenomas) 06/2014 - 04/2010
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Endotoxemia 01/2022
1	Periodontal Diseases (Periodontal Disease) 12/2021
1	Burns 12/2021
1	Cytokine Release Syndrome 12/2021
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 12/2021
1	Foreign-Body Reaction 10/2021
1	Colorectal Neoplasms (Colorectal Cancer) 10/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2021
1	Chronic Disease (Chronic Diseases) 01/2021
1	Musculoskeletal Diseases (Musculoskeletal Disease) 05/2020
1	Convalescence 05/2020
1	Abscess 01/2020
1	Hypertrophy 01/2020

Drug/Important Bio-Agent (IBA)

31	FibrinIBA 01/2022 - 01/2005
30	Fibrinogen (Factor I)FDA Link 01/2022 - 01/2005
18	estropipate (Ogen)FDA LinkGeneric 01/2022 - 01/2005
15	Thrombin FDA Link 05/2021 - 07/2007
11	PlasminogenIBA 01/2022 - 06/2014
10	Hemostatics (Antihemorrhagics)IBA 01/2022 - 01/2005
9	Fibrinolysin FDA Link 12/2021 - 08/2014
9	Peptide Hydrolases (Proteases)FDA Link 05/2021 - 09/2011
8	IntegrinsIBA 01/2022 - 03/2007
7	Prothrombin (Factor II)IBA 01/2021 - 07/2007
6	Blood Coagulation Factors (Coagulation Factor)IBA 01/2022 - 04/2010
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2010
5	CytokinesIBA 01/2022 - 06/2014
3	Proteinase-Activated ReceptorsIBA 05/2021 - 07/2007
3	Thromboplastin (Tissue Factor)IBA 05/2021 - 07/2007
3	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2021 - 06/2012
3	Factor XIII (Coagulation Factor XIII)IBA 01/2018 - 08/2014
3	TransglutaminasesIBA 01/2016 - 08/2014
2	Biocompatible Materials (Biomaterials)IBA 10/2021 - 12/2020
2	Plasminogen Activator Inhibitor 1IBA 01/2021 - 06/2012
2	AnticoagulantsIBA 01/2021 - 06/2011
2	EnzymesIBA 01/2021 - 01/2017
2	Plasminogen Activators (Plasminogen Activator)IBA 01/2021 - 03/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 04/2010
2	Biological ProductsIBA 12/2020 - 11/2018
2	Peptides (Polypeptides)IBA 01/2020 - 03/2007
2	LigandsIBA 01/2018 - 09/2011
2	ThrombomodulinIBA 08/2017 - 09/2011
2	AntithrombinsIBA 08/2017 - 11/2014
2	Dabigatran FDA Link 08/2017 - 11/2014
2	Virulence Factors (Pathogenicity Factors)IBA 06/2016 - 03/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2014 - 11/2007
2	Dextrans (Dextran)FDA Link 06/2014 - 04/2010
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 06/2014 - 04/2010
2	AzoxymethaneIBA 06/2014 - 04/2010
2	Macrophage-1 Antigen (Macrophage 1 Antigen)IBA 04/2010 - 11/2007
1	Small Interfering RNA (siRNA)IBA 01/2022
1	fibrin fragment D (D-dimer)IBA 01/2022
1	PolymersIBA 10/2021
1	Capsules (Microcapsules)IBA 10/2021
1	Focal Adhesion Protein-Tyrosine KinasesIBA 10/2021
1	RNA (Ribonucleic Acid)IBA 10/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2021
1	ImmunosorbentsIBA 01/2021
1	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA 01/2021
1	CoagulaseIBA 01/2021
1	B-Cell Activating FactorIBA 01/2021
1	Pharmaceutical PreparationsIBA 12/2020

Therapy/Procedure

3	Therapeutics 01/2019 - 04/2010
1	Lasers (Laser) 01/2022
1	Peritoneal Dialysis 01/2021
1	Indwelling Catheters (Indwelling Catheter) 01/2021
1	Ligation 01/2021
1	Precision Medicine 12/2020